Dosimertinib is a highly potent, selective, orally effective EGFR inhibitor for the study of non-small cell lung cancer.
Powder -20°C 3 years ; 4°C 2 years
In solvent -80°C 6 months ; -20°C 1 month
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
 Yvette N Lamb. Target Oncol. Osimertinib: A Review in Previously Untreated, EGFR Mutation-Positive, Advanced NSCLC
 Ying Cheng, et al. Target Oncol. Osimertinib Versus Comparator EGFR TKI as First-Line Treatment for EGFR-Mutated Advanced NSCLC: FLAURA China, A Randomized Study
 Sabine Schmid, et al. Lung Cancer. Mechanisms of osimertinib resistance and emerging treatment options
 Alessandro Leonetti, et al. Br J Cancer. Resistance mechanisms to osimertinib in EGFR-mutated non-small cell lung cancer
 J Remon, et al. Ann Oncol. Osimertinib and other third-generation EGFR TKI in EGFR-mutant NSCLC patients
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