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DODAP

Cat. No. M25509

All AbMole products are for research use only, cannot be used for human consumption.

DODAP Structure
Synonym:

1,2-Dioleoyl-3-dimethylammonium-propane

Size Price Availability Quantity
5mg USD 48  USD48 In stock
10mg USD 70  USD70 In stock
50mg USD 170  USD170 In stock
100mg USD 210  USD210 In stock
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Quality Control & Documentation
Biological Activity

DODAP is a cationic lipid. The ionizable lipid DODAP is a lipid component of the liposome. DODAP can be used to encapsulate siRNA, immunostimulatory chemotherapeutic agents for in vitro and in vivo delivery and so on.

1,2-Dioleoyl-3-dimethylammonium-propane (DODAP) is an ionizable cationic lipid (pKa = 5.59 in a TNS binding assay). It has been used as a component in liposomes that can be used to encapsulate siRNA, immunostimulatory oligodeoxynucleotides, antisense oligonucleotides, or chemotherapeutic agents for in vitro and in vivo delivery.

Chemical Information
Molecular Weight 648.05
Formula C41H77NO4
CAS Number 127512-29-2
Form Oily Liquid
Solubility (25°C) DMSO 90 mg/mL
Storage -20°C, protect from light, sealed
References

[1] Azizah Algarni, et al. Biomater Sci. In vivo delivery of plasmid DNA by lipid nanoparticles: the influence of ionizable cationic lipids on organ-selective gene expression

[2] Makhloufi Zoulikha, et al. Acta Pharm Sin B. Pulmonary delivery of siRNA against acute lung injury/acute respiratory distress syndrome

[3] Manuel J Carrasco, et al. Commun Biol. Ionization and structural properties of mRNA lipid nanoparticles influence expression in intramuscular and intravascular administration

[4] Mark Gontsarik, et al. J Colloid Interface Sci. pH-responsive aminolipid nanocarriers for antimicrobial peptide delivery

[5] Seigo Kimura, et al. J Control Release. Novel lipid combination for delivery of plasmid DNA to immune cells in the spleen

[6] P Mitrakos, et al. Biochemistry. Domains in cationic lipid plus polyelectrolyte bilayer membranes: detection and characterization via 2H nuclear magnetic resonance

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Keywords: DODAP, 1,2-Dioleoyl-3-dimethylammonium-propane supplier, Cell Transfection, inhibitors, activators

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