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Docusate Sodium

Cat. No. M5589
Docusate Sodium Structure
Synonym:

Aerosol OT, Bis(2-ethylhexyl) sulfosuccinate sodium salt, Constonate

Size Price Availability Quantity
100mg USD 60  USD60 In stock
500mg USD 180  USD180 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Docusate Sodium is a compound used to study constipation.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 444.56
Formula C20H37O7S.Na
CAS Number 577-11-7
Purity >98%
Solubility 88 mg/mL in DMSO
Storage at -20°C
References

[1] Ruston T, et al. Can Oncol Nurs J. Efficacy and side-effect profiles of lactulose, docusate sodium, and sennosides compared to PEG in opioid-induced constipation: a systematic review.

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Keywords: Docusate Sodium, Aerosol OT, Bis(2-ethylhexyl) sulfosuccinate sodium salt, Constonate supplier, Opioid Receptor, inhibitors

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