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DMP 543 is a acetylcholine release stimulator. Potently enhances K+-stimulated [3H]-ACh release from rat hippocampal slices (EC50 = 700 nM), and increases release of dopamine and glutamate (EC50 values are 0.25 and 0.22 μM, respectively). Orally active in vivo; increases ACh levels in rats (with a minimum effective dose of 1 mg/kg) and exerts a long duration of action. More potent than linopirdine both in vitro and in vivo. Also K+ channel blocker.
| Molecular Weight | 412.44 |
| Formula | C26H18F2N2O |
| CAS Number | 160588-45-4 |
| Solubility (25°C) | DMSO 41.24 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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