DMG-PEG 2000 is used for the preparation of liposome for siRNA delivery with improved transfection efficiency in vitro. DMG-PEG 2000 is also used for the lipid nanoparticle for an oral plasmid DNA delivery approach in vivo through a facile surface modification to improve the mucus permeability and delivery efficiency of the nanoparticles.
| Formula | (C2H4O)nC32H62O5 |
| CAS Number | 160743-62-4 |
| Solubility (25°C) | DMSO 90 mg/mL (ultrasonic and warming) Ethanol 90 mg/mL (Need ultrasonic) Water 15 mg/mL (Need ultrasonic) |
| Storage | -20°C, protect from light, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[4] S Moein Moghimi. Mol Ther. Allergic Reactions and Anaphylaxis to LNP-Based COVID-19 Vaccines
[5] Weiyu Zhao, et al. Cell Mol Bioeng. Lipid Polymer Hybrid Nanomaterials for mRNA Delivery
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