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Diltiazem hydrochloride is a calcium channel blocker that inhibits the transmembrane influx of extracellular calcium ions. Diltiazem hydrochloride is used in studies related to tumor and cardiovascular diseases. Diltiazem causes a dose-dependent inhibiton of contractions as well as Ca2+ influx stimulated by alpha adrenoceptor activation and high-K+ depolarization. Diltiazem also inhibits the Na-dependent Ca-efflux from heart mitochondria.
Diltiazem improves the cardiac microcirculation and function in an experimental model of hyperthyroidism in rats. Oral administration of diltiazem (100 mg/kg) reduces the blood pressure of SHR.
| Molecular Weight | 450.98 |
| Formula | C22H26N2O4S.HCl |
| CAS Number | 33286-22-5 |
| Solubility (25°C) | DMSO 60 mg/mL Water 30 mg/mL |
| Storage | 4°C, dry, sealed |
[2] D Harrington, et al. Diltiazem hydrochloride
[3] B F McGraw. Diltiazem hydrochloride
[4] B J McAuley, et al. The use of diltiazem hydrochloride in cardiovascular disorders
[5] K Abe, et al. Diltiazem hydrochloride: synthetic and pharmacological studies and development
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