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Diethylumbelliferyl phosphate

Cat. No. M7772

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Diethylumbelliferyl phosphate Structure

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Biological Activity

Diethylumbelliferyl phosphate is a selective, potent cholesterol esterase inhibitor. It blocks steroidogenesis primarily by preventing cholesterol transport into the mitochondria of steroidogenic cells. Inhibitors of cholesterol esterase are anticipated to limit the absorption of dietary cholesterol. IC50 = 11.6 μM.

Chemical Information
Molecular Weight 312.25
Formula C14H17O6P
CAS Number 897-83-6
Solubility (25°C) DMSO: ≥5 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Jin-Yong Chung, et al. Cholesterol accumulation, lipid droplet formation, and steroid production in Leydig cells: Role of translocator protein (18-kDa)

[2] Charlotte Simmons, et al. Platelet-activating factor antagonists enhance intracellular degradation of amyloid-β42 in neurons via regulation of cholesterol ester hydrolases

[3] Stephen A Brose, et al. A rapid oxygen exchange on prostaglandins in plasma represents plasma esterase activity that is inhibited by diethylumbelliferyl phosphate with high affinity

[4] Y S Choi, et al. Diethylumbelliferyl phosphate inhibits steroidogenesis by interfering with a long-lived factor acting between protein kinase A activation and induction of the steroidogenic acute regulatory protein (StAR)

[5] P M Gocze, et al. A cholesteryl ester hydrolase inhibitor blocks cholesterol translocation into the mitochondria of MA-10 Leydig tumor cells

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Keywords: Diethylumbelliferyl phosphate supplier, inhibitors, activators

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