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Diethylenetriaminepentaacetic acid

Cat. No. M9701
Diethylenetriaminepentaacetic acid Structure
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10g USD 40  USD40 In stock
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Biological Activity

Diethylenetriaminepentaacetic acid is a diethylenetriaminepentaacetic anhydride, which is a bifunctional chelating agent. It is used for the treatment of poisoning.

Chemical Information
Molecular Weight 393.35
Formula C14H23N3O10
CAS Number 67-43-6
Solubility (25°C) Water 5 mg/mL (20°C) 10mg/mL (50°C)
Storage 2-8°C, dry, protect from light, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Fanghui Wang, et al. Isotherm, kinetics, and adsorption mechanism studies of diethylenetriaminepentaacetic acid-modified banana/pomegranate peels as efficient adsorbents for removing Cd(II) and Ni(II) from aqueous solution

[2] Jiahui Xian, et al. Chemometric study on the electrochemical incineration of diethylenetriaminepentaacetic acid using boron-doped diamond anode

[3] Stephanie Channual, et al. Enhancements in hepatobiliary imaging: the spectrum of gadolinium-ethoxybenzyl diethylenetriaminepentaacetic acid usages in hepatobiliary magnetic resonance imaging

[4] Ha Young Lee, et al. Diethylenetriaminepentaacetic acid-gadolinium (DTPA-Gd)-conjugated polysuccinimide derivatives as magnetic resonance imaging contrast agents

[5] Sirpa Metsrinne, et al. Biological and photochemical degradation rates of diethylenetriaminepentaacetic acid (DTPA) in the presence and absence of Fe(III)

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