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Dianicline is a selective α4β2 nAChR partial agonist (IC50 = 105 nM). Exhibits >20-fold selectivity for α4β2 over other nAChR subtypes. Increases dopamine turnover in rat nucleus accumbens in vivo. Orally bioavailable.
| Molecular Weight | 289.2 |
| Formula | C13H16N2O.2HCl |
| CAS Number | 292634-27-6 |
| Solubility (25°C) | DMSO 5.78 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Hohmann, et al. Nature. An endocannabinoid mechanism for stress-induced analgesia.
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