Free shipping on all orders over $ 500

DG-8

Cat. No. M42101
DG-8 Structure
Size Price Availability Quantity
Free Delivery on orders over USD 500 Bulk Inquiry?
Quality Control & Documentation
Biological Activity

DG-8 is a potent inhibitor of STAT3-dependent transcription (IC50 0.98 μM).

Chemical Information
Molecular Weight 574.48
Formula C26H25Cl2N5O4S
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Paritosh Pande et al. Chem Res Toxicol. Site-Specific Incorporation of N-(2'-Deoxyguanosine-8-yl)-6-aminochrysene Adduct in DNA and Its Replication in Human Cells

[2] Yizhen Yin et al. Bioorg Med Chem. Effects of 8-halo-7-deaza-2'-deoxyguanosine triphosphate on DNA synthesis by DNA polymerases and cell proliferation

[3] Takashi Asahi et al. J Biol Chem. Chemical and immunochemical detection of 8-halogenated deoxyguanosines at early stage inflammation

[4] Siamak Haghdoost et al. Free Radic Res. Extracellular 8-oxo-dG as a sensitive parameter for oxidative stress in vivo and in vitro

[5] P M Gannett et al. Chem Res Toxicol. Base pairing of 8-oxoguanosine and 8-oxo-2'-deoxyguanosine with 2'-deoxyadenosine, 2'-deoxycytosine, 2'-deoxyguanosine, and thymidine

Related Fluorescent Dye Products
Zinquin

Zinquin is a zinc-sensitive, cell-impermeable fluorescent probe. Excitation (nm) 355, Emission (nm) 491
IRDye 800 NHS

IRDye 800 NHS is an active ester that can be used to label biomolecules, such as proteins and nucleic acids, in order to track and detect the dynamic behavior of these molecules in molecular biology research. IRDye 800CW NHS has good water solubility and can be bound to biomolecules, and the biomolecules still maintain their original biological activity after binding.
SOSG

SOSG (Singlet Oxygen Sensor Green Fluorescent Probe) is highly selective for singlet oxygen (1O2). It is commonly used for the detection of singlet oxygen in solutions and the evaluation of the efficacy of free radical scavengers.
FM1-43

FM1-43 is a very lipophilic, water-soluble styrene dyes, can specifically bind to cell membranes and inner membrane organelles to produce fluorescence. FM1-43 is widely used in endocytic and exospic membrane structure markers.
BCIP

BCIP is a chromogenic substrate for colorimetric assay of alkaline phosphatase activity.
  Catalog
Abmole Inhibitor Catalog




Keywords: DG-8 supplier, Fluorescent Dye, inhibitors, activators

 
Get to Know Us
Customer Support
Resources
Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.