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Dezamizumab

Cat. No. M24779
Dezamizumab Structure
Synonym:

GSK 2398852; Anti-Serum Amyloid P/SAP Reference Antibody

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Biological Activity

Dezamizumab (GSK 2398852) is a fully humanized recombinant monoclonal IgG1 anti-serum amyloid P component (SAP) antibody, with potential anti-amyloid activity. Dezamizumab triggers immunotherapeutic clearance of amyloid. Dezamizumab can be used in research of Amyloid light-chain (AL) amyloidosis.

Chemical Information
CAS Number 1662664-56-3
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Duncan Richards, et al. Orphanet J Rare Dis. An observational, non-interventional study for the follow-up of patients with amyloidosis who received miridesap followed by dezamizumab in a phase 1 study

[2] Ashutosh Wechalekar, et al. BMC Cardiovasc Disord. Pharmacodynamic evaluation and safety assessment of treatment with antibodies to serum amyloid P component in patients with cardiac amyloidosis: an open-label Phase 2 study and an adjunctive immuno-PET imaging study

[3] Jianhong Ma, et al. J Biol Chem. Novel methods to determine complement activation in human serum induced by the complex of Dezamizumab and serum amyloid P

[4] Tereza Popkova, et al. Br J Haematol. Monoclonal antibodies in the treatment of AL amyloidosis: co-targetting the plasma cell clone and amyloid deposits

[5] Mark B Pepys. Front Immunol. The Pentraxins 1975-2018: Serendipity, Diagnostics and Drυgs

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Keywords: Dezamizumab, GSK 2398852; Anti-Serum Amyloid P/SAP Reference Antibody supplier, inhibitors, activators

 
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