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Desmethyl Celecoxib

Cat. No. M20769

All AbMole products are for research use only, cannot be used for human consumption.

Desmethyl Celecoxib Structure

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Quality Control & Documentation
Biological Activity

Desmethyl Celecoxib (compound 3b), an analog of Celecoxib with the optimal yield of 75%, is a selective inhibitor of cyclooxygenase-2 (COX-2) with anti-inflammatory activities.

Chemical Information
Molecular Weight 367.35
Formula C16H12F3N3O2S
CAS Number 170569-87-6
Solubility (25°C) DMSO 73 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Jess Cebrecos, et al. Clin Ther. Celecoxib-tramadol co-crystal: A Randomized 4-Way Crossover Comparative Bioavailability Study

[2] Jaya Prabhakaran, et al. Bioorg Med Chem Lett. Radiosynthesis and in vivo evaluation of [11C]MOV as a PET imaging agent for COX-2

[3] Satheeshmanikandan R S Thappali, et al. Sci Pharm. Simultaneous Determination of Celecoxib, Erlotinib, and its Metabolite Desmethyl-Erlotinib (OSI-420) in Rat Plasma by Liquid chromatography/Tandem Mass Spectrometry with Positive/Negative Ion-Switching Electrospray Ionisation

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Carprofen inhibits canine COX2 with IC50 of 0.03 mM.

Diclofenac Diethylamine

Diclofenac diethylamine is a nonsteroidal anti-inflammatory compound taken to reduce inflammation and as an analgesic reducing pain in certain conditions.

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Keywords: Desmethyl Celecoxib supplier, COX, inhibitors, activators

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