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Deracoxib

Cat. No. M20527
Deracoxib Structure
Synonym:

SC-046

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Quality Control & Documentation
Biological Activity

Deracoxib is a COX-2 inhibitor with >48-fold selectivity over COX-1. It also exhibits inhibitory activity against phosphodiesterase (Ki = 3.6 μM against human PDE4D3).

Chemical Information
Molecular Weight 397.37
Formula C17H14F3N3O3S
CAS Number 169590-41-4
Solubility (25°C) DMSO 80 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Chao Wan, et al. J Org Chem. Copper-Catalyzed Reductive Ring-Cleavage of Isoxazoles: Synthesis of Fluoroalkylated Enaminones and Application for the Preparation of Celecoxib, Deracoxib, and Mavacoxib

[2] Tulay Bakirel, et al. Acta Vet Hung. Response of cultured normal canine mammary epithelial cells to deracoxib-doxorubicin combination

[3] B P Monteiro-Steagall, et al. J Vet Intern Med. Systematic review of nonsteroidal anti-inflammatory drug-induced adverse effects in dogs

[4] Safdar A Khan, et al. Vet Clin North Am Small Anim Pract. Toxicology of frequently encountered nonsteroidal anti-inflammatory drugs in dogs and cats

[5] Stephen R Royals, et al. Am J Vet Res. Investigation of the effects of deracoxib and piroxicam on the in vitro viability of osteosarcoma cells from dogs

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Keywords: Deracoxib, SC-046 supplier, COX, inhibitors, activators


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