Salmon refined deoxyribonucleic acid (SS-DNA) can be used to study the physical and chemical interactions of DNA with binders, inserters, modifiers, detection agents and densifiers. Salmon extract DNA was used to investigate the loading capacity of magnetic mesoporous silica nanoparticles (M-MSNs) and the bonding capacity of polymer nanolayer structures. SS-DNA can be used as a substrate for developing DNA detection methods.
| CAS Number | 438545-06-3 |
| Storage | 2-8°C |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[4] G Bonner, et al. Biotechnol Bioeng. Structural stability of DNA in nonaqueous solvents
[5] H L Tarr, et al. Can J Biochem. Deoxyribonucleic acid polymerase from immature testes of salmon
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