Free shipping on all orders over $ 500

DC_05

Cat. No. M8558
DC_05 Structure
Size Price Availability Quantity
5mg USD 400  USD400 In stock
10mg USD 550  USD550 In stock
25mg USD 780  USD780 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

DC_05 is a potent and selective non-nucleoside DNMT1 (DNA methyltransferase 1) inhibitor that significantly inhibits cancer cell proliferation.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 383.49
Formula C25H25N3O
CAS Number 890643-16-0
Purity >98%
Solubility DMSO 20 mg/mL
Storage at -20°C
References

[1] Subhrojit Sen, et al. Glycyrrhiza glabra alcoholic root extract ameliorates hyperglycemia, hyperlipidemia, and glycation-induced free iron-mediated oxidative reactions

[2] Amira Orabi, et al. Can Preoperative Characteristics Predict the Outcomes of Laparoscopic Cholecystectomy?

[3] Birgl Erdogan, et al. The Effect of Three Different Methods on Venipuncture Pain and Anxiety in Children: Distraction Cards, Virtual Reality, and Buzzy® (Randomized Controlled Trial)

[4] Felipe A Ribeiro, et al. Ultimate pH effects on dry-aged beef quality

[5] Hamad Algamaiah, et al. Conversion kinetics of rapid photo-polymerized resin composites

Related DNA Methyltransferase Products
γ-Oryzanol

γ-Oryzanol effectively inhibits DNA methyltransferases (DNMTs) in mouse striatum. Suppression of DNMT1 and DNMT3a,IC50 3.2 μM and 22.3 μM, respectively.

GSK3685032

GSK3685032 is a potent first-in-class DNMT1-selective inhibitor.

Bobcat339

Bobcat339 is a novel cytosine-based TET enzyme inhibitor with IC50s of 33 and 73 uM for TET1/2, it does not inhibit the DNA methyltransferase DNMT3a.

Vitamin D2

Vitamin D2 is a selective inhibitor of mammalian DNA polymerase A (pol A) with IC50 of 123 mM.

SGI-1027

SGI-1027 is a DNMT inhibitor with IC50 of 6, 8, 7.5 μM for DNMT1, DNMT3A, and DNMT3B

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: DC_05 supplier, DNA Methyltransferase, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.