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Cat. No. M8558
DC_05 Structure
Size Price Availability Quantity
5mg USD 400  USD400 In stock
10mg USD 550  USD550 In stock
25mg USD 780  USD780 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

DC_05 is a potent and selective non-nucleoside DNMT1 (DNA methyltransferase 1) inhibitor that significantly inhibits cancer cell proliferation.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 383.49
Formula C25H25N3O
CAS Number 890643-16-0
Purity >98%
Solubility DMSO 20 mg/mL
Storage at -20°C

[1] Subhrojit Sen, et al. Glycyrrhiza glabra alcoholic root extract ameliorates hyperglycemia, hyperlipidemia, and glycation-induced free iron-mediated oxidative reactions

[2] Amira Orabi, et al. Can Preoperative Characteristics Predict the Outcomes of Laparoscopic Cholecystectomy?

[3] Birgl Erdogan, et al. The Effect of Three Different Methods on Venipuncture Pain and Anxiety in Children: Distraction Cards, Virtual Reality, and Buzzy® (Randomized Controlled Trial)

[4] Felipe A Ribeiro, et al. Ultimate pH effects on dry-aged beef quality

[5] Hamad Algamaiah, et al. Conversion kinetics of rapid photo-polymerized resin composites

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Keywords: DC_05 supplier, DNA Methyltransferase, inhibitors

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