Valine is one of the 20 amino acids that make up protein. It is also an essential eight amino acids and sugar-generating amino acids for the human body. Valine can promote normal growth of the body, repair tissues, regulate blood sugar, and provide needed energy.
Molecular Weight | 117.15 |
Formula | C5H11NO2 |
CAS Number | 640-68-6 |
Solubility (25°C) | Water 50 mg/mL |
Storage | RT, dry, sealed |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
Related Metabolite/Endogenous Metabolite Products |
---|
2,3-Dihydroxyisovaleric acid
2,3-Dihydroxyisovaleric acid is a natural metabolite of the branched-chain amino acid leucine. It acts by activating the mTOR signaling pathway to promote the synthesis of new muscle proteins and reduce the breakdown of existing proteins. |
Ursocholic acid
Ursocholic acid is a bile acid found predominantly in bile of mammals, which can be transformed into deoxycholic acid by the intestinal microflora in mice. |
5β-Cholanic acid
5β-Cholanic acid can be used for 5β-Cholanic acid derivatives synthesis. |
D-Thyroxine
D-Thyroxine is a thyroid hormone that can inhibit TSH secretion. D-Thyroxine can be used for the research of hypercholesterolemia. |
Allolithocholic acid
Allolithocholic acid is a steroid acid could found in normal serum and feces. Allolithocholic acid facilitates excretion, absorption, and transport of fats and sterols in the intestine and liver. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.