D-Cycloserine is an analog of the amino acid D-alanine.
| Molecular Weight | 102.09 |
| Formula | C3H6N2O2 |
| CAS Number | 68-41-7 |
| Solubility (25°C) | 1 mg/mL warmed in DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related NMDA Products |
|---|
| Esketamine
Esketamine (ESK) is an NMDA-receptor antagonist. |
| Glypromate
Glypromate (Gly-Pro-Glu) is a neuroactive peptide with a potent action on acetylcholine release. Glypromate (Gly-Pro-Glu) is a weak NMDA receptor agonist binds to N-methyl-D-aspartate (NMDA) receptor with an IC50 value of 14.7 μM. |
| Radiprodil (RGH-896)
Radiprodil (also known as RGH-896) is an orally active and selective NMDA receptors antagonist which was evaluated as potential treatment of neuropathic pain associated with diabetic peripheral neuropathy (DPNP). |
| Trans-crocetin
Trans-crocetin (Croceic Acid) is a blood-brain barrier-permeable NMDA receptor antagonist with high affinity, extracted from saffron (Crocus sativus L.). *The compound is unstable in solutions, freshly prepared is recommended |
| L-Glutamic acid monosodium salt hydrate
L-Glutamic acid monosodium salt hydrate is also a Kainate receptor, NMDA receptor and quisqualate receptor agonist; an excitatory amino acid neurotransmitter. |
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