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D-87503 is a potent PI3K/Akt/mTOR signaling pathway inhibitor with IC50 of 62nM and 0.76μM for PI3K and Erk2, respectively. In cellular assays, D-87503 also effectively suppressed the target downstream substrates Akt and Rsk1 kinase of the PI3K/Akt/mTOR signaling pathway. D-87503 inhibited several carcinoma cell lines, including BxPC3, Hct116, MDA-MB 468 and 231 with EC50 of median 5µM.
| Molecular Weight | 337.4 |
| Formula | C17H15N5OS |
| CAS Number | 800394-83-6 |
| Solubility (25°C) | DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related PI3K Products |
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| RV-1729
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| Vulolisib
Vulolisib is a potent and orally active phosphatidylinositol 3-kinase (PI3K) inhibitor, with IC50 values of 0.2 nM, 168 nM, 90 nM and 49 nM for PI3Kα, PI3Kβ, PI3Kγ and PI3Kδ, respectively. |
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Vps34-IN-4 is a potent, selective, and orally active inhibitor of VPS34. |
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