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Cytosporone B is a naturally occurring Nur77 (NR4A1) agonist (Kd = 8.52 x 10-7 M). Cytosporone B induces apoptosis in gastric cancer cells in vitro. Cytosporone B increases blood glucose levels in fasting C57 mice and suppresses xenograft tumor growth. Cytosporone B also exhibits a potent antifibrotic effect in bleomycin-induced skin fibrosis in vivo. In the hepatocytes of wild-type mice, the transcriptional activity of the reporter is induced five-fold with cytosporone B treatment. In wild-type mice, cytosporone B treatment significantly increases glucose levels from 3.2 to 11.4 mM within the first 30 min, and thereafter blood glucose gradually decreased before reaching the initial level after 300 min.
| Molecular Weight | 322.4 |
| Formula | C18H26O5 |
| CAS Number | 321661-62-5 |
| Solubility (25°C) | DMSO 50 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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