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CYT-1010

Cat. No. M10564
CYT-1010 Structure
Synonym:

CYT1010

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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

CYT-1010 is a mu-opioid receptor agonist with EC50s of 13.1 nM and 0.0053 nM on beta-arrestin recruitment and inhibition of cAMP production, respectively.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 624.73
Formula C35H40N6O5
CAS Number 213769-33-6
Purity >98%
Solubility DMSO ≥ 60 mg/mL
Storage at -20°C
References

[1] Lynn Webster, et al. Pain Med. Dilemma of Addiction and Respiratory Depression in the Treatment of Pain: A Prototypical Endomorphin as a New Approach

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Keywords: CYT-1010, CYT1010 supplier, Opioid Receptor, inhibitors

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