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Cyclophosphamide monohydrate

Cat. No. M3671
Cyclophosphamide monohydrate Structure
Synonym:

Cyclophosphamide hydrate

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
50mg USD 30  USD30 In stock
100mg USD 48  USD48 In stock
500mg USD 72  USD72 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Cyclophosphamide monohydrate is a nitrogen mustard alkylating agent, it attaches the alkyl group to the guanine base of DNA.

*The compound is unstable in solutions, freshly prepared is recommended

Product Citations
Chemical Information
Molecular Weight 279.1
Formula C7H15Cl2N2O2P.H2O
CAS Number 6055-19-2
Solubility (25°C) Water 40 mg/mL
DMSO 35 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Bhushan Munjal, et al. Crystallization of Cyclophosphamide Monohydrate During Lyophilization

[2] Martina Ahlmann, et al. The effect of cyclophosphamide on the immune system: implications for clinical cancer therapy

[3] Janet Kim, et al. Cyclophosphamide in dermatology

[4] Ashkan Emadi, et al. Cyclophosphamide and cancer: golden anniversary

[5] S Tsukagoshi. Cyclophosphamide

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