Cyclophosphamide monohydrate is a nitrogen mustard alkylating agent, it attaches the alkyl group to the guanine base of DNA.
*The compound is unstable in solutions, freshly prepared is recommended
Neurourol Urodyn. 2024 Feb.
Multi-omics analyses uncover metabolic signatures and gene expression profiles of interstitial cystitis/bladder pain syndrome
Cyclophosphamide monohydrate purchased from AbMole
BMC Biol. 2021 May 20;19(1):108.
Very long intergenic non-coding (vlinc) RNAs directly regulate multiple genes in cis and trans
Cyclophosphamide monohydrate purchased from AbMole
Molecular Weight | 279.1 |
Formula | C7H15Cl2N2O2P.H2O |
CAS Number | 6055-19-2 |
Solubility (25°C) | Water 40 mg/mL DMSO 35 mg/mL |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Bhushan Munjal, et al. Crystallization of Cyclophosphamide Monohydrate During Lyophilization
[3] Janet Kim, et al. Cyclophosphamide in dermatology
[4] Ashkan Emadi, et al. Cyclophosphamide and cancer: golden anniversary
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