Free shipping on all orders over $ 500

Cyclo(-RGDfK)

Cat. No. M10209
Cyclo(-RGDfK) Structure
Synonym:

Cyclo(-Arg-Gly-Asp-D-Phe-Lys)

Size Price Availability Quantity
5mg USD 135  USD135 In stock
10mg USD 215  USD215 In stock
25mg USD 400  USD400 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Cyclo (-RGDfK) is an effective and specific αvβ3 integrin inhibitor. Cyclo (-RGDfK) has a high affinity for purified integrin (Kd = 41.70 nM). In athymic mice bearing α(v)β(3)-integrin-positive C6 gliomas, Cyclo (-RGDfK) modification induces less tumor metabolic activity, less tumor progression, fewer intratumoral vessels.

Chemical Information
Molecular Weight 603.67
Formula C27H41N9O7
CAS Number 161552-03-0
Solubility (25°C) Water 60 mg/mL
DMSO 70 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] V Lopez-Rodriguez, et al. Nucl Med Biol. Preparation and preclinical evaluation of (66)Ga-DOTA-E(c(RGDfK))2 as a potential theranostic radiopharmaceutical

Related Integrin Products
HSDVHK-NH2

HSDVHK-NH2 is an antagonist of the integrin αvβ3-vitronectin interaction, with an IC50 of 1.74 pg/mL (2.414 pM).

LDV

LDV, a tripeptide, is a non-fluorescent analog of LDV-FITC.

Cyclo(RADfK)

Cyclo(RADfK) is a selective α(v)β(3) integrin ligand that has been extensively used for research, therapy, and diagnosis of neoangiogenesis.

Obtustatin

Obtustatin is a non-RGD disintegrin of 41 residues.

Integrin Binding Peptide

Integrin Binding Peptide is derived by fibronectin.

  Catalog
Abmole Inhibitor Catalog




Keywords: Cyclo(-RGDfK), Cyclo(-Arg-Gly-Asp-D-Phe-Lys) supplier, Integrin, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.