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Cyanine 5 maleimide

Cat. No. M21419
Cyanine 5 maleimide Structure
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1mg USD 500  USD500 In stock
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Quality Control & Documentation
Biological Activity

Cy5 maleimide is a fluorescent dye and various cyanidin 5 (Cy5) dyes have been used to label biomolecules for fluorescent imaging and other fluorescence-based biochemical analyses. They are widely used to label peptides, proteins, and oligonucleotides, among others. The maximum excitation/emission wavelength is 651/670 nm.

Chemical Information
Molecular Weight 892.96
Solubility (25°C) Soluble in DMSO
Storage -20°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Ming-Yue Wu, et al. Autophagy. PI3KC3 complex subunit NRBF2 is required for apoptotic cell clearance to restrict intestinal inflammation

[2] Wooram Um, et al. Bioconjug Chem. A Comparative Study on Albumin-Binding Molecules for Targeted Tumor Delivery through Covalent and Noncovalent Approach

[3] Yanjiao Li, et al. J Colloid Interface Sci. Facile preparation of near-infrared fluorescence and magnetic resonance dual-modality imaging probes based on mesoporous organosilica nanoparticles

[4] Stefanie Arndt, et al. Angew Chem Int Ed Engl. "Photoclick" postsynthetic modification of DNA

[5] Huiming Zhang. Cy5.5-CGRRRQRRKKRG-Labeled T lymphocytes

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