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Curdlan

Cat. No. M10415
Curdlan Structure
Size Price Availability Quantity
500mg USD 60  USD60 In stock
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Quality Control & Documentation
Biological Activity

Curdlan is a polysaccharide produced by bacteria and a homopolymer of glucose with β-1,3-glucosidic linkage.

Chemical Information
Formula (C6H10O5)n
CAS Number 54724-00-4
Storage 2-8°C, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Paulina Zelechowska, et al. Cell Immunol. Curdlan stimulates tissue mast cells to synthesize pro-inflammatory mediators, generate ROS, and migrate via Dectin-1 receptor

[2] Rubaiya Yunus Basha, et al. Mater Sci Eng C Mater Biol Appl. Dimethylaminoethyl modified curdlan nanoparticles for targeted siRNA delivery to macrophages

[3] Qianru Li, et al. Food Sci Nutr. Curdlan enhances the structure of myosin gel model

[4] Shikha Negi, et al. Front Microbiol. Curdlan Limits Mycobacterium tuberculosis Survival Through STAT-1 Regulated Nitric Oxide Production

[5] Ruoran Zhang, et al. Biomacromolecules. Properties, chemistry, and applications of the bioactive polysaccharide curdlan

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