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Cucurbitacin E is a natural compound which from the climbing stem of Cucumic melo L, which significantly suppresses the activity of the cyclin B1/CDC2 complex.
| Cell Experiment | |
|---|---|
| Cell lines | The colorectal cancer (CRC) cells |
| Preparation method | The colorectal cancer (CRC) cells are seeded into 96-well culture plates at 5000 cells/well. The cells are treated with 0, 2.5, 5, and 7.5 μM Cucurbitacin E for 1-3 days. MTT dye (1 mg/mL) is added to each well for at least 4 h of treatment. The reaction is stopped by the addition of DMSO, and optical density is measured at 540 nm on a multi-well plate reader. Background absorbance of the medium in the absence of cells is subtracted. All samples are assayed in triplicate, and the mean for each experiment is calculated. Results are expressed as a percentage of control, which is considered as 100%. Each assay is carried out in triplicate, and the results are expressed as the mean. |
| Concentrations | 0, 2.5, 5, and 7.5 μM |
| Incubation time | 1-3 days |
| Animal Experiment | |
|---|---|
| Animal models | C57BL/6 male mice |
| Formulation | |
| Dosages | 0.25, 0.5 mg/kg/day |
| Administration | oral gavage |
| Molecular Weight | 556.69 |
| Formula | C32H44O8 |
| CAS Number | 18444-66-1 |
| Solubility (25°C) | DMSO 30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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| CDK9-IN-1
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| XO44
XO44 (PF-6808472) is a broad-spectrum covalent kinase probe. |
| ML 315
ML 315 is a selective dual inhibitor of CDK and DYRK with IC50s of 68 nM and 282 nM, respectively. |
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