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CS-2660 (JNJ-38158471)

Cat. No. M20715

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CS-2660 (JNJ-38158471) Structure
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Biological Activity

CS-2660 (JNJ-38158471) is a well tolerated, orally available, highly selective VEGFR-2 inhibitor with IC50 of 40 nM. CS-2660 (JNJ-38158471) also inhibits closely related tyrosine kinases such as Ret and Kit with IC50 of 180 nM and 500 nM,while it has no significant activity (>1 microM) against VEGFR-1 and VEGFR-3.

Chemical Information
Molecular Weight 364.79
Formula C15H17ClN6O3
CAS Number 951151-97-6
Solubility (25°C) DMSO 30 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Kenneth R LaMontagne, et al. Angiogenesis. A highly selective, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor has potent activity in vitro and in vivo

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  Catalog
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Keywords: CS-2660 (JNJ-38158471) supplier, VEGFR/PDGFR, inhibitors, activators

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