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CPYPP

Cat. No. M14675

All AbMole products are for research use only, cannot be used for human consumption.

CPYPP Structure
Size Price Availability Quantity
5mg USD 85  USD85 In stock
10mg USD 133  USD133 In stock
25mg USD 249  USD249 In stock
50mg USD 397  USD397 In stock
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Quality Control & Documentation
Biological Activity

CPYPP is a DOCK2-Rac1 interaction inhibitor. CPYPP binds to DOCK2 DHR-2 domain and inhibits the guanine nucleotide exchange factor (GEF) activity of DOCK2DHR-2 for Rac1 in a dose-dependent manner with an IC50 of 22.8 µM. CPYPP also inhibits DOCK180 and DOCK5 and less inhibits DOCK9.

Chemical Information
Molecular Weight 324.76
CAS Number 310460-39-0
Solubility (25°C) DMSO 25 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Xiaotao Xu, et al. DOCK2 contributes to endotoxemia-induced acute lung injury in mice by activating proinflammatory macrophages

[2] Marina G Ferrari, et al. Identifying and treating ROBO1 -ve /DOCK1 +ve prostate cancer: An aggressive cancer subtype prevalent in African American patients

[3] Momo Morikawa, et al. The Molecular Motor KIF21B Mediates Synaptic Plasticity and Fear Extinction by Terminating Rac1 Activation

[4] Yann Ferrandez, et al. Allosteric inhibition of the guanine nucleotide exchange factor DOCK5 by a small molecule

[5] Akihiko Nishikimi, et al. Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK2

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Keywords: CPYPP supplier, inhibitors, activators

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