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CP 99994 dihydrochloride is a high affinity NK1 antagonist (Ki = 0.145 nM in vitro). Also displays high ex vivo binding potency in gerbil striatum (IC50 = 36.8 nM). Attenuates endothelium-dependent contraction induced by substance P.
| Molecular Weight | 369.33 |
| Formula | C19H24N2O.2HCl |
| CAS Number | 145148-39-6 |
| Solubility (25°C) | Water 36.93 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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