Coumarin 7 is a coumarin laser dye in plants in the form of glycosides.
| Molecular Weight | 333.38 |
| Formula | C20H19N3O2 |
| CAS Number | 27425-55-4 |
| Form | Solid |
| Solubility (25°C) | DMSO 25 mg/mL (ultrasonic and warming) |
| Storage | -20°C, protect from light |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[3] Yongke Lu et al. Curr Pharm Des. Cytochrome P450s and Alcoholic Liver Disease
[4] O Pelkonen et al. Toxicology. CYP2A6: a human coumarin 7-hydroxylase
[5] O Pelkonen et al. J Cancer Res Clin Oncol. Regulation of coumarin 7-hydroxylation in man
| Related Fluorescent Dye Products |
|---|
| Zinquin
Zinquin is a zinc-sensitive, cell-impermeable fluorescent probe. Excitation (nm) 355, Emission (nm) 491 |
| IRDye 800 NHS
IRDye 800 NHS is an active ester that can be used to label biomolecules, such as proteins and nucleic acids, in order to track and detect the dynamic behavior of these molecules in molecular biology research. IRDye 800CW NHS has good water solubility and can be bound to biomolecules, and the biomolecules still maintain their original biological activity after binding. |
| SOSG
SOSG (Singlet Oxygen Sensor Green Fluorescent Probe) is highly selective for singlet oxygen (1O2). It is commonly used for the detection of singlet oxygen in solutions and the evaluation of the efficacy of free radical scavengers. |
| FM1-43
FM1-43 is a very lipophilic, water-soluble styrene dyes, can specifically bind to cell membranes and inner membrane organelles to produce fluorescence. FM1-43 is widely used in endocytic and exospic membrane structure markers. |
| BCIP
BCIP is a chromogenic substrate for colorimetric assay of alkaline phosphatase activity. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.
