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Colcemid

Cat. No. M11477
Colcemid Structure
Synonym:

Demecolcine

Size Price Availability Quantity
1mg USD 220  USD220 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Colcemid (Demecolcine) is an effective mitotic inhibitor. Colcemid binds tubulin and blocks cells for metaphase karyotype analysis. Colcemid can induce apoptosis and can be used in tumor research.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 371.43
Formula C21H25NO5
CAS Number 477-30-5
Purity >99%
Solubility DMSO ≥ 20 mg/mL
Storage 2-8°C
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Keywords: Colcemid, Demecolcine supplier, Microtubule, inhibitors

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