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Colcemid

Cat. No. M11477
Colcemid Structure
Synonym:

Demecolcine

Size Price Availability Quantity
1mg USD 40  USD40 In stock
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Quality Control & Documentation
Biological Activity

Colcemid (Demecolcine) is an effective mitotic inhibitor. Colcemid binds tubulin and blocks cells for metaphase karyotype analysis. Colcemid can induce apoptosis and can be used in tumor research.

Chemical Information
Molecular Weight 371.43
Formula C21H25NO5
CAS Number 477-30-5
Solubility (25°C) DMSO ≥ 20 mg/mL
Storage 2-8°C
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Stefan Florian, et al. Methods Mol Biol. Anti-Microtubule Drugs

[2] Joohyeong Lee, et al. Mol Reprod Dev. Colcemid treatment during oocyte maturation improves preimplantation development of cloned pig embryos by influencing meiotic progression and cytoplasmic maturation

[3] T W SHEEHY, et al. AMA Arch Intern Med. Demecolcine (colcemid) toxicity

[4] K A Rubin, et al. Cell Mol Biol (Noisy-le-grand). Effect of colcemid on the centrosome and microtubules in dermal melanophores of Xenopus laevis larvae in vivo

[5] C L Rieder, et al. J Cell Sci. Colcemid and the mitotic cycle

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Keywords: Colcemid, Demecolcine supplier, Animal Modeling, inhibitors, activators


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