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Coenzyme A is an essential cofactor in all living cells synthesized by Vitamin B5, ATP, and cysteine. Covalent binding of Coenzyme A to peroxidase 5 (Prdx5) results in complete inhibition of peroxidase activity, which can be reversed by DTT reduction. Coenzyme A and its thioester derivatives are key participants in major catabolic, anabolic pathways and regulation of gene expression. Many human pathologies, including cancer, diabetes, and neurodegeneration, are associated with abnormal biosynthesis and homeostasis of Coenzyme A and its derivatives.
| Molecular Weight | 767.53 |
| Formula | C21H36N7O16P3S |
| CAS Number | 85-61-0 |
| Solubility (25°C) | DMSO 50 mg/mL Water 50 mg/mL |
| Storage | 4°C, protect from light, dry, sealed |
[2] Ivan Gout. Biochem Soc Trans. Coenzyme A: a protective thiol in bacterial antioxidant defence
[4] Hao Yang, et al. Biochem Soc Trans. Hereditary diseases of coenzyme A thioester metabolism
| Related Metabolite/Endogenous Metabolite Products |
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| Oleamide
Oleamide is an endogenous fatty acid amide. |
| Deoxycarnitine chloride
Deoxycarnitine chloride is angiopathic substance produced as an intermediary metabolite by gut microbiota. |
| Monobutyl phthalate
Monobutyl phthalate, a major metabolite of dibutyl phthalate (DBP), possesses antiandrogenic effects. Monobutyl phthalate is an embryotoxicant. |
| Testosterone sulfate (pyridinium)
Testosterone sulfate pyridinium is a Testosterone sulfate with a pyridinium. Testosterone sulfate is the metabolite of Testosterone. |
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