Coenzyme A is an essential cofactor in all living cells synthesized by Vitamin B5, ATP, and cysteine. Covalent binding of Coenzyme A to peroxidase 5 (Prdx5) results in complete inhibition of peroxidase activity, which can be reversed by DTT reduction. Coenzyme A and its thioester derivatives are key participants in major catabolic, anabolic pathways and regulation of gene expression. Many human pathologies, including cancer, diabetes, and neurodegeneration, are associated with abnormal biosynthesis and homeostasis of Coenzyme A and its derivatives.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
|Solubility||DMSO ≥ 10 mg/mL|
|Storage||4°C , protect from light , dry , sealed|
|Related Endogenous Metabolite Products|
7-ketolithocholic acid (3α -hydroxy-7-oxo-5 β-cholanic acid) is a derivative of cholcholic acid, which can be absorbed to inhibit endogenous bile acid production and bile cholesterol secretion. Cholic acid is also used as a cholic acid derivative of TGR5 regulators.
|Taurodeoxycholate sodium salt
Taurodeoxycholate sodium salt is a bile salt formed in the liver by conjugation of deoxycholate with taurine, usually as the sodium salt. It is used as a cholagogue and choleretic, also industrially as a fat emulsifier.
Trichloroacetic acid (TCA) is derived from trichloroethylene (TCE) metabolism. It can be used as an acid decalcifier. Trichloroacetic acid, a metabolite of Trichloroacetic acid, is believed to contribute to its liver cancer effect in mice.
|S-Adenosyl-L-methionine disulfate tosylate
S-adenosyl-l-methionine disulfate tosylate (Ademetionine disulfate tosylate) is the main biomethyl donor synthesized in all mammalian cells, but is most abundant in liver. Ademetionine has anti-inflammatory activity and has been used in studies of chronic liver disease.
Enoxolone (Glycyrrhetin) is a β -aromatic resin alcohol pentacyclic triterpenoid derivative obtained by Glycyrrhetin hydrolysis, with anti-ulcer, anti-inflammatory and anti-proliferation properties.
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