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Coenzyme A

Cat. No. M11468
Coenzyme A Structure
Size Price Availability Quantity
5mg USD 75  USD75 In stock
10mg USD 105  USD105 In stock
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Quality Control
  • Current batch:
  • Purity >90%
  • COA
  • MSDS
Biological Activity

Coenzyme A is an essential cofactor in all living cells synthesized by Vitamin B5, ATP, and cysteine. Covalent binding of Coenzyme A to peroxidase 5 (Prdx5) results in complete inhibition of peroxidase activity, which can be reversed by DTT reduction. Coenzyme A and its thioester derivatives are key participants in major catabolic, anabolic pathways and regulation of gene expression. Many human pathologies, including cancer, diabetes, and neurodegeneration, are associated with abnormal biosynthesis and homeostasis of Coenzyme A and its derivatives.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 767.53
Formula C21H36N7O16P3S
CAS Number 85-61-0
Purity >90%
Solubility DMSO ≥ 10 mg/mL
Storage 4°C , protect from light , dry , sealed
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Keywords: Coenzyme A supplier, Endogenous Metabolite, inhibitors

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