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Coenzyme A is an essential cofactor in all living cells synthesized by Vitamin B5, ATP, and cysteine. Covalent binding of Coenzyme A to peroxidase 5 (Prdx5) results in complete inhibition of peroxidase activity, which can be reversed by DTT reduction. Coenzyme A and its thioester derivatives are key participants in major catabolic, anabolic pathways and regulation of gene expression. Many human pathologies, including cancer, diabetes, and neurodegeneration, are associated with abnormal biosynthesis and homeostasis of Coenzyme A and its derivatives.
| Molecular Weight | 767.53 |
| Formula | C21H36N7O16P3S |
| CAS Number | 85-61-0 |
| Solubility (25°C) | DMSO 50 mg/mL Water 50 mg/mL |
| Storage | 4°C, protect from light, dry, sealed |
[2] Ivan Gout. Biochem Soc Trans. Coenzyme A: a protective thiol in bacterial antioxidant defence
[4] Hao Yang, et al. Biochem Soc Trans. Hereditary diseases of coenzyme A thioester metabolism
| Related Metabolite/Endogenous Metabolite Products |
|---|
| 1-Palmitoyl-sn-glycero-3-phosphocholine
1-Palmitoyl-sn-glycero-3-phosphocholine is an lysophosphatidylcholine. 1-Palmitoyl-sn-glycero-3-phosphocholine exhibits proinflammatory activity. 1-Palmitoyl-sn-glycero-3-phosphocholine can be used in the research of atherosclerosis. |
| L-Citrulline DL-Malate
L-Citrulline DL-malate is an organic compound commonly used as a nutritional supplement. It boosts the body's production of nitrogen oxides, improves circulation and athletic performance, and reduces muscle fatigue. In addition, L-Citrulline DL-malate can be used in the field of agriculture to enhance plant immunity. |
| Creatine-d3
Creatine-d3 is the deuterium labeled Creatine. Creatine is an endogenous amino acid derivative, which plays an important role in cellular energy, especially in muscle and brain. |
| Creatinine-d3
Creatinine-d3 is a deuterium labeled Creatinine. Creatinine is a break-down product of creatine phosphate in muscle. |
| Urolithin M7
Urolithin M7 is a metabolite, which is derived from the transformation of ellagitannins, compounds found predominantly in pomegranates, berries, and nuts. This transformation occurs via intestinal microbiota, which convert ellagitannins into various urolithins, including Urolithin M7. Its mode of action involves influencing cellular processes, potentially modulating mitochondrial function and autophagy pathways. |
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