Free shipping on all orders over $ 500

CMFDA

Cat. No. M21548
CMFDA Structure
Size Price Availability Quantity
1mg USD 300  USD300 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

CMFDA is a cell-permeable fluorescent probe that can be used as a cellular tracer. CMFDA can be cleaved by non-specific esterases common to living cells, producing a fluorescent compound, fluorescein, visible using a fluorescent microscope.

Chemical Information
Molecular Weight 464.85
Formula C25H17ClO7
CAS Number 136832-63-8
Storage -20°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Ming-Yue Wu, et al. Autophagy. PI3KC3 complex subunit NRBF2 is required for apoptotic cell clearance to restrict intestinal inflammation

[2] Gi-Hoon Nam, et al. J Immunol Methods. An optimized protocol to determine the engulfment of cancer cells by phagocytes using flow cytometry and fluorescence microscopy

[3] Jiexi Wang, et al. PLoS One. Correlation between the In Vitro Functionality of Stored Platelets and the Cytosolic Esterase-Induced Fluorescence Intensity with CMFDA

[4] Hector Trejo-Chvez, et al. Exp Parasitol. In vitro evaluation of the effects of cysticidal drugs in the Taenia crassiceps cysticerci ORF strain using the fluorescent CellTracker CMFDA

[5] X P Yang, et al. Biotechniques. Use of CMFDA and CMTMR fluorescent dyes in FACS-based antibody screening

Related Fluorescent Dye Products
Zinquin

Zinquin is a zinc-sensitive, cell-impermeable fluorescent probe. Excitation (nm) 355, Emission (nm) 491

IRDye 800 NHS

IRDye 800 NHS is an active ester that can be used to label biomolecules, such as proteins and nucleic acids, in order to track and detect the dynamic behavior of these molecules in molecular biology research. IRDye 800CW NHS has good water solubility and can be bound to biomolecules, and the biomolecules still maintain their original biological activity after binding.

SOSG

SOSG (Singlet Oxygen Sensor Green Fluorescent Probe) is highly selective for singlet oxygen (1O2). It is commonly used for the detection of singlet oxygen in solutions and the evaluation of the efficacy of free radical scavengers.

FM1-43

FM1-43 is a very lipophilic, water-soluble styrene dyes, can specifically bind to cell membranes and inner membrane organelles to produce fluorescence. FM1-43 is widely used in endocytic and exospic membrane structure markers.

BCIP

BCIP is a chromogenic substrate for colorimetric assay of alkaline phosphatase activity.

  Catalog
Abmole Inhibitor Catalog




Keywords: CMFDA supplier, Fluorescent Dye, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.