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CM-272

Cat. No. M9442
CM-272 Structure
Synonym:

CM272

Size Price Availability Quantity
5mg USD 180  USD180 In stock
10mg USD 320  USD320 In stock
50mg USD 720  USD720 In stock
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Quality Control & Documentation
Biological Activity

CM-272 is a first-in-class, reversible dual small molecule inhibitor of G9a and DNMTs in hematologic malignancies. The IC50 of CM-272 inhibited G9a, DNMT1, DNMT3A, DNMT3B and GLP were 8 nM, 382 nM, 85 nM, 1200 nM and 2 nM, respectively.

Chemical Information
Molecular Weight 478.63
Formula C28H38N4O3
CAS Number 1846570-31-7
Solubility (25°C) DMSO
saline
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] San Jose-Eneriz E, et al. Nat Commun. Discovery of first-in-class reversible dual small molecule inhibitors against G9a and DNMTs in hematological malignancies.

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  Catalog
Abmole Inhibitor Catalog




Keywords: CM-272, CM272 supplier, Histone Methyltransferase, inhibitors, activators


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