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Cilostazol

Cat. No. M5519
Cilostazol Structure
Synonym:

OPC-13013

Size Price Availability Quantity
50mg USD 50  USD50 In stock
100mg USD 90  USD90 In stock
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Quality Control
Biological Activity

Cilostazol is a potent cyclic nucleotide phosphodiesterase type 3 (PDE3) inhibitor with IC50 of 0.2 μM and inhibitor of adenosine uptake.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 369.46
Formula C20H27N5O2
CAS Number 73963-72-1
Purity >98%
Solubility 74 mg/mL in DMSO
Storage at -20°C
References

[1] Bedenis R, et al. Cochrane Database Syst Rev. Cilostazol for intermittent claudication.

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Keywords: Cilostazol, OPC-13013 supplier, PDE, inhibitors

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