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Cilostazol

Cat. No. M5519
Cilostazol Structure
Synonym:

OPC-13013

Size Price Availability Quantity
50mg USD 45  USD50 In stock
100mg USD 81  USD90 In stock
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Quality Control
Biological Activity

Cilostazol is a potent cyclic nucleotide phosphodiesterase type 3 (PDE3) inhibitor with IC50 of 0.2 μM and inhibitor of adenosine uptake.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 369.46
Formula C20H27N5O2
CAS Number 73963-72-1
Purity >98%
Solubility 74 mg/mL in DMSO
Storage at -20°C
References

Cilostazol for intermittent claudication.
Bedenis R, et al. Cochrane Database Syst Rev. 2014 Oct 31;(10):CD003748. PMID: 25358850.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Cilostazol, OPC-13013 supplier, PDE, inhibitors

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