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Ciliobrevin D is a cell-permeable, reversible and specific inhibitor of AAA+ ATPase motor cytoplasmic dynein. Ciliobrevin D inhibits Hedgehog (Hh) signaling and primary cilia formation. Ciliobrevin D inhibits dynein-dependent microtubule gliding and ATPase activity in vitro.
| Molecular Weight | 392.62 |
| CAS Number | 1370554-01-0 |
| Solubility (25°C) | DMSO 5 mg/mL (ultrasonic and warming and heat to 60°C) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Csaba Harasztosi, et al. Vesicle traffic in the outer hair cell
[3] Jennifer van der Horst, et al. Dynein regulates Kv7.4 channel trafficking from the cell membrane
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