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Cholic acid

Cat. No. M9192

All AbMole products are for research use only, cannot be used for human consumption.

Cholic acid Structure
Size Price Availability Quantity
100mg USD 30  USD30 In stock
500mg USD 50  USD50 In stock
1g USD 70  USD70 In stock
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Quality Control & Documentation
Biological Activity

Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion.

Protocol (for reference only)
Cell Experiment
Cell lines HepG2 cells
Preparation method HepG2 cells are pretreated with the inhibitors NaN3 (1 mg/mL), Genistein (50 μg/mL), MβCD (10 mM), Nystatin (50 μg/mL), Chlorpromazine (10 μg/mL), and Cholic acid (1 mg/mL) for 30 min. After removing the inhibitors, the cells are incubated with CA-LPs for 2 h, and the cellular uptake of LPs is determined in the "In vitro cellular uptake assays" section.
Concentrations 1 mg/mL
Incubation time 30 min
Animal Experiment
Animal models Tg-CYP2D6 mice
Formulation 1% (w/w) Cholic acid-supplemented
Dosages 14 days
Administration fed
Chemical Information
Molecular Weight 408.57
Formula C24H40O5
CAS Number 81-25-4
Solubility (25°C) DMSO: ≥ 40 mg/mL
Storage 4°C, dry, sealed
References

[1] Li Y, et al. Int J Nanomedicine. Mechanism of hepatic targeting via oral administration of DSPE-PEG-cholic acid-modified nanoliposomes.

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