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Cholesterol 5α,6α-epoxide

Cat. No. M39576
Cholesterol 5α,6α-epoxide Structure
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Biological Activity

Cholesterol-5α,6α-epoxide is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Chemical Information
Molecular Weight 402.65
Formula C27H46O2
CAS Number 1250-95-9
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Amna Ghith et al. J Steroid Biochem Mol Biol. The oxidation of cholesterol derivatives by the CYP124 and CYP142 enzymes from Mycobacterium marinum

[2] Alzbeta Kloudova-Spalenkova et al. J Steroid Biochem Mol Biol. Plasma oxysterol levels in luminal subtype breast cancer patients are associated with clinical data

[3] Po Lin Liao et al. Toxicol Lett. 7-Ketocholesterol and cholesterol-5alpha,6alpha-epoxide induce smooth muscle cell migration and proliferation through the epidermal growth factor receptor/phosphoinositide 3-kinase/Akt signaling pathways

[4] F Müller et al. Eur J Biochem. Visualization of a covalent intermediate between microsomal epoxide hydrolase, but not cholesterol epoxide hydrolase, and their substrates

[5] J T Chan et al. J Invest Dermatol. Distribution of cholesterol-5alpha,6alpha-epoxide formation and its metabolism in mouse skin

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