Chlorazol Black E is an azo dye. Chlorozol Black E is a chitin-specific stain and used to detect fungal filaments. Chlorazol Black E (Direct Black 38) can induce unscheduled DNA synthesis in liver and micronucleus in bone marrow of rats in vivo.
Chlorazol Black E (Direct Black 38) is slightly soluble in water for green light black, and adequate soluble in alcohol for green light blue-black. The strong sulfuric acid is a deep red in blue, diluted Purple dark reddish brown for to red light black precipitation; In nitric acid solution for yellow brown; In strong hydrochloric acid for dark red light black solution. For cellulose fiber dyeing, the dye absorbency is very good.
| Molecular Weight | 781.73 |
| Formula | C34H25N9Na2O7S2 |
| CAS Number | 1937-37-7 |
| Form | Solid |
| Solubility (25°C) | Water 5 mg/mL DMSO 10 mg/mL |
| Storage | 4°C, protect from light, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[4] H E WILCOX. Stain Technol. STAINING PLANT TISSUES WITH CHLORAZOL BLACK E AND PIANESE III-B
[5] L Kass. Am J Clin Pathol. Staining of granulocytic cells by Chlorazol black E
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