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Chloranil

Cat. No. M40891
Chloranil Structure
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Biological Activity

Chloranil is a fungicide that can be used to treat seeds and bulbs of crops against fungal diseases.

Chemical Information
Molecular Weight 245.88
Formula C6Cl4O2
CAS Number 118-75-2
Form Liquid
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Tatsuki Hanada et al. J Chem Phys. Neutral-to-ionic photoinduced phase transition of tetrathiafulvalene-p-chloranil by electronic and vibrational excitation: A real-time nuclear-electronic dynamics simulation study

[2] Hiroyuki Ishida. IUCrdata. Bis[2-(2-hy-droxy-phen-yl)-1 H-benzimidazol-3-ium] chloranilate

[3] N L Asfandiarov et al. J Chem Phys. Dissociative electron attachment to p-fluoranil and p-chloranil

[4] Armin Dengl et al. J Chem Phys. Evolution of ferroelectricity in tetrathiafulvalene-p-chloranil as a function of pressure and temperature

[5] C Pac et al. Photochem Photobiol. Chloranil-photosensitized monomerization of dimethylthymine cyclobutane dimers and effect of magnesium perchlorate

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