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Chitobiose dihydrochloride

Cat. No. M31264
Chitobiose dihydrochloride Structure
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5mg USD 400  USD400 In stock
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Biological Activity

Chitobiose dihydrochloride, a chitosan oligosaccharide, is a dimer of β-1,4-linked glucosamine units.

Chemical Information
Molecular Weight 413.25
Formula C12H26Cl2N2O9
CAS Number 115350-24-8
Form Solid
Solubility (25°C) Water >100 mg/mL (Need ultrasonic)
Storage Powder -20°C
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Fakhra Liaqat, et al. J Basic Microbiol. Characterization of different chitosanases of Bacillus strains and their application in chitooligosaccharides production

[2] Meng Wang, et al. Int J Mol Sci. Characterization of Stackebrandtia nassauensis GH 20 Beta-Hexosaminidase, a Versatile Biocatalyst for Chitobiose Degradation

[3] Masafumi Hidaka, et al. Structure. Chitobiose phosphorylase from Vibrio proteolyticus, a member of glycosyl transferase family 36, has a clan GH-L-like (alpha/alpha)(6) barrel fold

[4] S Zamze, et al. Eur J Biochem. A family of novel, acidic N-glycans in Bowes melanoma tissue plasminogen activator have L2/HNK-1-bearing antennae, many with sulfation of the fucosylated chitobiose core

[5] S Nishimura, et al. Carbohydr Res. Synthesis of a peripheral trisaccharide sequence of lutropin, a pituitary glycoprotein hormone; use of chitobiose as a key starting material

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