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CHAPS

Cat. No. M19964
CHAPS Structure
Size Price Availability Quantity
500mg USD 45  USD45 In stock
1g USD 55  USD55 In stock
5g USD 100  USD100 In stock
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Quality Control
  • Current batch:
  • Purity 99%
  • COA
  • MSDS
Biological Activity

CHAPS is a non-denaturing, zwitterionic detergent that dissolves membrane proteins. CHAPS are used to stabilize various protein-DNA complexes and can preserve the biochemical activity of proteins in solution. CHAPS is often used as a detergent in the solubilization and purification of membrane proteins for several advantageous reasons. CHAPS detergent is non-denaturing to membrane proteins, can solubilize proteins, disaggregate protein-protein interactions and is electrically neutral. CHAPS is also useful in ion exchange chromatography and isoelectric focusing as it is zwitterionic and does not exhibit a net charge between pH 2 to 12. The critical micelle concentration of CHAPS is 6-10mM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 614.88
Formula C32H58N2O7S
CAS Number 75621-03-3
Purity 99%
Solubility Water ≥ 50 mg/mL
Storage 2-8°C, dry, sealed
References

[1] P M Rodi, et al. Biochim Biophys Acta . Comparative study of the interaction of CHAPS and Triton X-100 with the erythrocyte membrane

[2] Ana Kroflic, et al. Langmuir. Thermodynamic characterization of 3-[(3-cholamidopropyl)-dimethylammonium]-1-propanesulfonate (CHAPS) micellization using isothermal titration calorimetry: temperature, salt, and pH dependence

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