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Chaetominine

Cat. No. M30909

All AbMole products are for research use only, cannot be used for human consumption.

Chaetominine Structure
Synonym:

(-)-Chaetominine

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Quality Control & Documentation
Biological Activity

Chaetominine is an alkaloidal metabolite. Chaetominine has cytotoxicity against human leukemia K562 and colon cancer SW1116 cell lines. Chaetominine reduces MRP1-mediated agent resistance via inhibiting PI3K/Akt/Nrf2 signaling pathway in K562/Adr human leukemia cells.

Chemical Information
Molecular Weight 402.4
Formula C22H18N4O4
CAS Number 918659-56-0
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Hui Geng, et al. Chem Rec. Rapid Generation of Molecular Complexity by Chemical Synthesis: Highly Efficient Total Synthesis of Hexacyclic Alkaloid (-)-Chaetominine and Its Biosynthetic Implications

[2] Jingyun Yao, et al. Oncol Lett. Chaetominine induces cell cycle arrest in human leukemia K562 and colon cancer SW1116 cells

[3] Jingyun Yao, et al. Biochem Biophys Res Commun. Chaetominine reduces MRP1-mediated drug resistance via inhibiting PI3K/Akt/Nrf2 signaling pathway in K562/Adr human leukemia cells

[4] Barry B Snider, et al. Org Lett. Synthesis of (-)-chaetominine

[5] Rui H Jiao, et al. Org Lett. Chaetominine, a cytotoxic alkaloid produced by endophytic Chaetomium sp. IFB-E015

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Keywords: Chaetominine, (-)-Chaetominine supplier, PI3K, inhibitors, activators

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