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CGP36742

Cat. No. M8360

All AbMole products are for research use only, cannot be used for human consumption.

CGP36742 Structure

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Quality Control & Documentation
Biological Activity

CGP36742 was the first orally active GABAB-selective antagonist. The IC50 for blocking GABAergic transmission is 36 μM. Oral administration of CGP36742 in rats blocks baclofen-induced neuronal depression, and reduces learning deficit and passive avoidance in an olfactory bulbectomy depression model.

Chemical Information
Molecular Weight 179.2
Formula C7H18NO2P
CAS Number 123690-78-8
Solubility (25°C) Water: 10 mg/mL (warmed)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Roger Bullock. SGS-742 Novartis

[2] Graham A R Johnston, et al. GABA(C) receptors as drug targets

[3] Y Nakagawa, et al. The GABA(B) receptor antagonist CGP36742 improves learned helplessness in rats

[4] Y Nakagawa, et al. The GABA(B) receptor antagonist CGP36742 attenuates the baclofen- and scopolamine-induced deficit in Morris water maze task in rats

[5] Z Yu, et al. Mechanism of colchicine impairment on learning and memory, and protective effect of CGP36742 in mice

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Keywords: CGP36742 supplier, inhibitors, activators

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