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CGH 2466 dihydrochloride

Cat. No. M6581

All AbMole products are for research use only, cannot be used for human consumption.

CGH 2466 dihydrochloride Structure

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Quality Control & Documentation
Biological Activity

CGH 2466 dihydrochloride is a adenosine A1, A2B and A3 receptor antagonist (IC50 values are 19, 21, and 80 nM respectively). Also inhibits p38 MAPK (IC50 = 187 - 400 nM) and phosphodiesterase type 4D (IC50 = 22 nM). Displays potent anti-inflammatory effects in vitro and in vivo. Potentially useful for asthma and chronic obstructive pulmonary disease (COPD) research.

Chemical Information
Molecular Weight 395.13
Formula C14H9N3SCl2.2HCl
CAS Number 1177618-54-0
Solubility (25°C) DMSO 3.95 mg/mL (with gentle warming)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Allen, et al. Semin Oncol. CI-1040 (PD184252), a targeted signal transduction inhibitor of MEK (MAPKK).

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Keywords: CGH 2466 dihydrochloride supplier, inhibitors, activators

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