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CFI-400437 

Cat. No. M27875

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CFI-400437  Structure

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Quality Control & Documentation
Biological Activity

CFI-400437 is an indolinone-derived, ATP-competitive kinase inhibitor with high selectivity for PLK4 (IC50 of 0.6 nM).

Chemical Information
Molecular Weight 492.57
Formula C29H28N6O2
CAS Number 1169211-37-3
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Amreena Suri, et al. Int J Mol Sci. Evaluation of Protein Kinase Inhibitors with PLK4 Cross-Over Potential in a Pre-Clinical Model of Cancer

[2] Radoslaw Laufer, et al. J Med Chem. The discovery of PLK4 inhibitors: (E)-3-((1H-Indazol-6-yl)methylene)indolin-2-ones as novel antiproliferative agents

Related PLK Products
(1E)-CFI-400437 dihydrochloride 

(1E)-CFI-400437 dihydrochloride is a potent PLK4 (IC50= 0.6 nM) inhibitor and selective against other members of the PLK family (>10 μM).

3MB-PP1

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  Catalog
Abmole Inhibitor Catalog




Keywords: CFI-400437  supplier, PLK, inhibitors, activators

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