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CAY10404

Cat. No. M10099
CAY10404 Structure
Synonym:

CAY-10404

Size Price Availability Quantity
10mg USD 180  USD180 In stock
25mg USD 360  USD360 In stock
50mg USD 640  USD640 In stock
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Quality Control & Documentation
Biological Activity

CAY10404 is one of the most selective inhibitors of COX-2 (IC50 = 1 nM) over COX-1. CAY10404 is also a potent PKB/Akt and MAPK signaling pathways inhibitor and induces apoptosis in non-small cell lung cancer (NSCLC) cells. CAY10404 compromises the ability of H460 cells to form colonies in anchorage-independent growth in a concentration-dependent manner. In vivo, CAY10404 (50 mg/kg/day; i.p.; 4 days) decreases lung inflammation in HTV mice and attenuates ventilator-induced lung injury.

Chemical Information
Molecular Weight 367.34
Formula C17H12F3NO3S
CAS Number 340267-36-9
Solubility (25°C) DMSO ≥ 90 mg/mL
Storage -20°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Joshua A Robertson, et al. Am J Respir Cell Mol Biol. The role of cyclooxygenase-2 in mechanical ventilation-induced lung injury

[2] Yongseon Cho, et al. Respirology. Effects of CAY10404 on the PKB/Akt and MAPK pathway and apoptosis in non-small cell lung cancer cells

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Keywords: CAY10404, CAY-10404 supplier, COX, inhibitors, activators


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