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CAY10404 is one of the most selective inhibitors of COX-2 (IC50 = 1 nM) over COX-1. CAY10404 is also a potent PKB/Akt and MAPK signaling pathways inhibitor and induces apoptosis in non-small cell lung cancer (NSCLC) cells. CAY10404 compromises the ability of H460 cells to form colonies in anchorage-independent growth in a concentration-dependent manner. In vivo, CAY10404 (50 mg/kg/day; i.p.; 4 days) decreases lung inflammation in HTV mice and attenuates ventilator-induced lung injury.
| Molecular Weight | 367.34 |
| Formula | C17H12F3NO3S |
| CAS Number | 340267-36-9 |
| Solubility (25°C) | DMSO ≥ 90 mg/mL |
| Storage | -20°C, dry, sealed |
| Related COX Products |
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| Firocoxib
Firocoxib is a selective COX-2 inhibitor exhibiting high selectivity to inhibit COX-2. |
| Ampiroxicam
Ampiroxicam is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory compound. |
| Bufexamac
Bufexamac is a COX inhibitor for IFN-α release with EC50 of 8.9 μM. |
| Carprofen
Carprofen inhibits canine COX2 with IC50 of 0.03 mM. |
| Diclofenac Diethylamine
Diclofenac diethylamine is a nonsteroidal anti-inflammatory compound taken to reduce inflammation and as an analgesic reducing pain in certain conditions. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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