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CAY10404 is one of the most selective inhibitors of COX-2 (IC50 = 1 nM) over COX-1. CAY10404 is also a potent PKB/Akt and MAPK signaling pathways inhibitor and induces apoptosis in non-small cell lung cancer (NSCLC) cells. CAY10404 compromises the ability of H460 cells to form colonies in anchorage-independent growth in a concentration-dependent manner. In vivo, CAY10404 (50 mg/kg/day; i.p.; 4 days) decreases lung inflammation in HTV mice and attenuates ventilator-induced lung injury.
| Molecular Weight | 367.34 |
| Formula | C17H12F3NO3S |
| CAS Number | 340267-36-9 |
| Solubility (25°C) | DMSO ≥ 90 mg/mL |
| Storage | -20°C, dry, sealed |
| Related COX Products |
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| Sudoxicam
Sudoxicam is a reversible and orally active COX antagonist and a non-steroidal anti-inflammatory agent from the enol-carboxamide class. |
| Metyrosine
Metyrosine is a selective tyrosine hydroxylase enzyme inhibitor. Metyrosine significantly inhibits high COX-2 activity. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. |
| PPOH
PPOH, a fatty acid derivative, is a selective cyclooxygenase (COX) inhibitor that inhibits arachidonic acid cyclooxygenase activity in renal cortical microsomes. |
| Tenidap
Tenidap, a non-steroidal anti-inflammatory drug, is a selective COX-1 inhibitor, with IC50 values of 0.03 μM and 1.2 μM for COX-1 and COX-2, respectively. |
| COX-2-IN-6
COX-2-IN-6 is an orally active, gut-restricted and selective cyclooxygenase-2 (COX-2) inhibitor for colorectal Chemoprevention of cancer. |
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Products are for research use only. Not for human use. We do not sell to patients.
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