CAY10404 is one of the most selective inhibitors of COX-2 (IC50 = 1 nM) over COX-1. CAY10404 is also a potent PKB/Akt and MAPK signaling pathways inhibitor and induces apoptosis in non-small cell lung cancer (NSCLC) cells. CAY10404 compromises the ability of H460 cells to form colonies in anchorage-independent growth in a concentration-dependent manner. In vivo, CAY10404 (50 mg/kg/day; i.p.; 4 days) decreases lung inflammation in HTV mice and attenuates ventilator-induced lung injury.
Molecular Weight | 367.34 |
Formula | C17H12F3NO3S |
CAS Number | 340267-36-9 |
Solubility (25°C) | DMSO ≥ 90 mg/mL |
Storage | -20°C, dry, sealed |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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