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BTZO-1

Cat. No. M8232

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BTZO-1 Structure

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Quality Control & Documentation
Biological Activity

BTZO-1 is a suppressor of cardiomyocyte apoptosis presumably by activation of antioxidant response element (ARE)-mediated gene expression. BTZO-1 binds to the macrophage migration inhibitory factor (MIF) that is required to activate the glutathione S-transferase Ya subunit (GST Ya) gene ARE.

Chemical Information
Molecular Weight 240.28
Formula C13H8N2OS
CAS Number 99420-15-2
Solubility (25°C) DMSO: ≥7 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Mansour Aboelenain, et al. Antioxidant response element activator, BTZO-1, improves the developmental competence of bovine oocytes

[2] Hiroshi Yukitake, et al. Macrophage Migration Inhibitory Factor as an Emerging Drug Target to Regulate Antioxidant Response Element System

[3] Hiroshi Yukitake, et al. BTZO-2, an antioxidant response element-activator, provides protection against lethal endotoxic shock in mice

[4] Hiroshi Yukitake, et al. BTZO-15, an ARE-activator, ameliorates DSS- and TNBS-induced colitis in rats

[5] Haruhide Kimura, et al. BTZO-1, a cardioprotective agent, reveals that macrophage migration inhibitory factor regulates ARE-mediated gene expression

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Keywords: BTZO-1 supplier, inhibitors, activators

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