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Brevilin A

Cat. No. M17579

All AbMole products are for research use only, cannot be used for human consumption.

Brevilin A Structure
Size Price Availability Quantity
1mg USD 115  USD115 In stock
5mg USD 270  USD270 In stock
10mg USD 400  USD400 In stock
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Quality Control & Documentation
Biological Activity

Brevilin A is an orally active STAT3/JAK inhibitor, with IC50 of 10.6 μM against STAT3. Brevilin A shows anti-tumor activity, anti-proliferative activity to cancer cells, and can induce apoptosis and autophagy.

Chemical Information
Molecular Weight 346.42
Formula C20H26O5
CAS Number 16503-32-5
Solubility (25°C) DMSO 80 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Yong Joo Park, et al. Bioorg Med Chem Lett. Anti-fibrotic effects of brevilin A in hepatic fibrosis via inhibiting the STAT3 signaling pathway

[2] Marta Muscianese, et al. Dermatol Ther. Alopecia areata treated with topical and systemic brevilin A: A case series

[3] Zhao Qu, et al. Onco Targets Ther. Brevilin A, a Natural Sesquiterpene Lactone Inhibited the Growth of Triple-Negative Breast Cancer Cells via Akt/mTOR and STAT3 Signaling Pathways

[4] Xiaoli Zhang, et al. Viruses. Brevilin A, a Sesquiterpene Lactone, Inhibits the Replication of Influenza A Virus In Vitro and In Vivo

[5] Rui Liu, et al. Front Pharmacol. Brevilin A Induces Cell Cycle Arrest and Apoptosis in Nasopharyngeal Carcinoma

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Keywords: Brevilin A supplier, Sesquiterpenoids, inhibitors, activators

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