BRD5529 is an effective dose-dependent CARD9-TRIM62 protein–protein interaction (PPI) inhibitor with an IC50 value of 8.6 μM. BRD5529 has potency and complete inhibition of CARD9 ubiquitinylation in vitro, also has favorable solubility. BRD5529 can be used for the research of inflammatory bowel disease (IBD) such as Crohn’s disease (CD) and ulcerative colitis (UC).
Molecular Weight | 465.54 |
Formula | C25H31N5O4 |
CAS Number | 1358488-78-4 |
Form | Solid |
Solubility (25°C) | DMSO 125 mg/mL (ultrasonic) |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
Related E1/E2/E3 Enzyme Products |
---|
NX-1607
NX-1607 is an oral, small molecule inhibitor of casitas B-lineage lymphoma proto-oncogene-b (Cbl-b) that has been shown to enhance antigen recall, reduce T cell exhaustion and increase cytokine production upon T cell receptor stimulation, overcoming suppressive signals from the tumor microenvironment (TME). |
SENP1-IN-1
SENP1-IN-1 is a specific deSUMOylation protease 1 (SENP1) inhibitor. SENP1-IN-1 can be used for tumor radiosensitivity enhancement. |
TRAF6 peptide
TRAF6 peptide is a specific TRAF6-p62 inhibitor. |
LTP001
LTP001 is a SMURF1 antagonist that can be used in studies related to idiopathic pulmonary fibrosis (IPF). |
HECT E3-IN-1
HECT E3-IN-1 is a HECT E3 ligase inhibitor. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.