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BRD5529 

Cat. No. M28241

All AbMole products are for research use only, cannot be used for human consumption.

BRD5529  Structure

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Quality Control & Documentation
Biological Activity

BRD5529 is an effective dose-dependent CARD9-TRIM62 protein–protein interaction (PPI) inhibitor with an IC50 value of 8.6 μM. BRD5529 has potency and complete inhibition of CARD9 ubiquitinylation in vitro, also has favorable solubility. BRD5529 can be used for the research of inflammatory bowel disease (IBD) such as Crohn’s disease (CD) and ulcerative colitis (UC).

Chemical Information
Molecular Weight 465.54
Formula C25H31N5O4
CAS Number 1358488-78-4
Form Solid
Solubility (25°C) DMSO 125 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Theodore J Kottom, et al. Drugs R D. Preclinical and Toxicology Studies of BRD5529, a Selective Inhibitor of CARD9

[2] Suhadinie Gamage, et al. Biochem Pharmacol. CARD9 mediates glucose-stimulated insulin secretion in pancreatic beta cells

[3] Theodore J Kottom, et al. Antimicrob Agents Chemother. Targeting CARD9 with Small-Molecule Therapeutics Inhibits Innate Immune Signaling and Inflammatory Response to Pneumocystis carinii β-Glucans

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Keywords: BRD5529  supplier, E1/E2/E3 Enzyme, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
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