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Borrelidin is an antibiotic and antiangiogenic compound. Selective inhibition of ThrRS. It showed antiangiogenic activity in mouse tumor angiogenesis model. Apoptosis of capillary endothelial cells was induced. Destroy capillaries and inhibit capillaries formation (IC50 = 0.8 nM in rat aorta). Induce the unfolded protein response (UPR) and apoptosis of oral cancer cells.
| Molecular Weight | 489.64 |
| Formula | C28H43NO6 |
| CAS Number | 7184-60-3 |
| Solubility (25°C) | DMSO 0.98 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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